Across TCGA pan-cancer cohorts, SCARNA21B RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SCARNA21B’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where SCARNA21B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SCARNA21B is over-expressed in tumor.
BRCA and KIRC are the cancer types where SCARNA21B tumor–normal differential expression is most reproducible.