SCAP

Across TCGA patient cohorts, SCAP protein abundance is significantly associated with the RNA expression of many other genes, with 3,457 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SCAP-associated genes across cancer lineages are CTSW, LRP1, and OR1A1. Each is linked with SCAP in more than 2 cancer types. Because this analysis shows association rather than direction, both SCAP-to-partner and partner-to-SCAP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCAP versus CTSW in COAD, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAP→partner) and Y-score (partner→SCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CTSW →	-1.159	-0.534	<.001	<.001	3	3
UCEC	LRP1 →	-0.812	-0.359	.005	.003	3	2
PDAC	OR1A1 →	-0.062	-1.285	.003	<.001	3	2
PDAC	OR2A15P →	+0.364	+0.844	.002	<.001	3	2
HNSC	OR2AO1P →	+0.632	+0.337	.009	.005	3	2
HNSC	ZNF619 →	+0.537	+0.495	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,457 associations by consensus.

SCAP vs CTSW — COAD

Explore this scatter interactively →