SCAI

Across TCGA patient cohorts, SCAI mutation is significantly associated with the RNA expression of many other genes, with 1,387 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCAI-associated genes across cancer lineages are RNU6-497P, VDAC1P12, and RNU6-633P. Each is linked with SCAI in more than 2 cancer types. Because this analysis shows association rather than direction, both SCAI-to-partner and partner-to-SCAI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-497P grouped by SCAI-low versus SCAI-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAI→partner) and Y-score (partner→SCAI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-497P →	+0.340	+3.792	<.001	.004	3	3
CESC	VDAC1P12 →	+0.036	+4.384	<.001	.008	3	2
COAD	RNU6-633P →	+0.419	+3.374	<.001	.008	3	2
LUAD	LINC02046 →	+0.818	+3.273	<.001	.009	3	2
LUAD	LINC01901 →	+0.863	+3.819	<.001	.005	3	2
SKCM	RN7SL429P →	+0.130	+5.219	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,387 associations by consensus.

RNU6-497P by SCAI expression — BLCA

Explore this box plot interactively →