SCAI

Across TCGA pan-cancer cohorts, SCAI RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SCAI’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SCAI RNA is repressed in tumor relative to normal tissue. In most cancer types SCAI is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and LIHC are the cancer types where SCAI tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCAI RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−1.430	<.001	9	view →
LUSC	Male	All	−0.742	<.001	7	view →
LIHC	All	All	+0.272	<.001	7	view →
KIRC	All	All	−0.244	.002	6	view →
CHOL	All	II,III,IV	+1.520	<.001	5	view →
KICH	All	All	−0.524	<.001	4	view →
HNSC	All	III,IV	+0.261	.022	4	view →
UCEC	All	All	−0.573	<.001	2	view →
KIRP	Male	All	−0.325	.011	2	view →
BRCA	Female	All	−0.173	.026	2	view →
STAD	Male	II,III,IV	+0.495	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SCAI–LUAD

Open the LUAD breakdown →