SCAI

Across TCGA cell cohorts, SCAI mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SCAI-associated genes across cancer lineages are C10orf71, SCGB1C1, and PRAMEF15. Each is linked with SCAI in more than 1 cancer types. Because this analysis shows association rather than direction, both SCAI-to-partner and partner-to-SCAI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf71 grouped by SCAI-low versus SCAI-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCAI→partner) and Y-score (partner→SCAI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C10orf71 →	+0.016	+4.981	<.001	.008	3	1
CNS	SCGB1C1 →	+0.201	+4.981	<.001	.008	3	1
CNS	PRAMEF15 →	+0.352	+4.981	<.001	.008	3	1
CNS	LEUTX →	+0.181	+5.321	<.001	.005	3	1
CNS	MBD3L2 →	+1.117	+4.981	.001	.008	3	1
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

C10orf71 by SCAI expression — CNS

Explore this box plot interactively →