SBF2

Across TCGA patient cohorts, SBF2 mutation is significantly associated with the RNA expression of many other genes, with 4,777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SBF2-associated genes across cancer lineages are BTBD6, MIS18A, and CDT1. Each is linked with SBF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SBF2-to-partner and partner-to-SBF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTBD6 grouped by SBF2-low versus SBF2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBF2→partner) and Y-score (partner→SBF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BTBD6 →	+0.636	+3.254	<.001	<.001	3	4
UCEC	MIS18A →	+0.372	+1.152	.001	.003	3	4
UCEC	CDT1 →	+0.674	+1.684	<.001	<.001	3	4
UCEC	TK1 →	+0.387	+3.269	.003	<.001	3	4
UCEC	ENO1 →	+0.337	+1.753	.004	<.001	3	4
COAD	RCC1 →	+0.510	+3.754	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,777 associations by consensus.

BTBD6 by SBF2 expression — SKCM

Explore this box plot interactively →