SASS6

Across TCGA patient cohorts, SASS6 mutation is significantly associated with the RNA expression of many other genes, with 1,093 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SASS6-associated genes across cancer lineages are OR13Z3P, SAP30, and SLC1A3. Each is linked with SASS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SASS6-to-partner and partner-to-SASS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13Z3P grouped by SASS6-low versus SASS6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SASS6→partner) and Y-score (partner→SASS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR13Z3P →	+0.129	+6.837	<.001	<.001	3	2
UCEC	SAP30 →	+0.740	+3.021	<.001	<.001	3	2
UCEC	SLC1A3 →	+1.007	+2.321	.003	.006	3	2
LUAD	ACER2P1 →	+0.101	+4.194	<.001	.009	3	2
LUAD	MIR449C →	+0.439	+5.087	.001	.004	3	2
CESC	OR4P1P →	+0.223	+7.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,093 associations by consensus.

OR13Z3P by SASS6 expression — CESC

Explore this box plot interactively →