SASS6

Across TCGA pan-cancer cohorts, SASS6 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SASS6 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SASS6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SASS6 expression acts as an unfavorable survival marker, although some lineages such as READ and GBM show a favorable association.

KIRP, ACC, and LIHC are the cancer types where SASS6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.786	0.916	<.001	129	view →
ACC	DFS	Median	All	0.390	0.752	<.001	100	view →
LIHC	OS	Tertile	All	0.576	0.784	<.001	79	view →
KICH	DFS	Quartile	II,III,IV	0.317	0.937	.001	77	view →
MESO	DFS	Quartile	All	0.198	0.511	<.001	69	view →
LGG	DFS	Median	All	0.655	0.822	<.001	52	view →
READ	OS	Median	III,IV	0.724	0.265	<.001	28	view →
LUAD	OS	Median	All	0.760	0.860	<.001	27	view →
GBM	DFS	Median	All	0.393	0.175	<.001	24	view →
THYM	OS	Tertile	II,III,IV	1.000	0.634	.004	23	view →
SARC	DFS	Quartile	All	0.400	0.727	.002	16	view →
SKCM	DFS	Quartile	II,III,IV	0.384	0.215	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SASS6–KIRP (DFS)

Open the KIRP breakdown →