SARS1

Across TCGA patient cohorts, SARS1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SARS1-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with SARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SARS1-to-partner and partner-to-SARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SARS1-low versus SARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SARS1→partner) and Y-score (partner→SARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.127	-2.558	.001	.010	3	1
UCEC	eEF2 →	+0.496	+2.415	<.001	.003	3	1
UCEC	EGFR_pY1068 →	-0.360	-3.807	<.001	<.001	3	1
UCEC	GATA6 →	-0.187	-2.985	.004	.034	3	1
UCEC	ACVRL1 →	-0.146	-2.986	.007	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.251	-3.074	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

14-3-3_beta by SARS1 expression — UCEC

Explore this box plot interactively →