SAMM50

Across TCGA cell cohorts, SAMM50 mutation is significantly associated with the mutation status of many other genes, with 4,730 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SAMM50-associated genes across cancer lineages are GGA1, EEF2K, and CLIP3. Each is linked with SAMM50 in more than 2 cancer types. Because this analysis shows association rather than direction, both SAMM50-to-partner and partner-to-SAMM50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GGA1 grouped by SAMM50-low versus SAMM50-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMM50→partner) and Y-score (partner→SAMM50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GGA1 →	+4.050	+3.870	.002	.002	1	3
BLOOD_Leukemia	EEF2K →	+3.050	+3.247	.008	.008	1	3
BLOOD_Leukemia	CLIP3 →	+3.635	+3.635	.003	.003	1	3
BLOOD_Leukemia	ZNF574 →	+5.050	+4.700	<.001	<.001	1	3
BLOOD_Leukemia	TRIM62 →	+4.635	+4.145	.001	.001	1	3
BLOOD_Leukemia	STAT3 →	+3.050	+3.247	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,730 associations by consensus.

GGA1 by SAMM50 expression — BLOOD_Leukemia

Explore this box plot interactively →