SAMM50

Across TCGA pan-cancer cohorts, SAMM50 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SAMM50’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SAMM50 RNA is repressed in tumor relative to normal tissue. In most cancer types SAMM50 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, LIHC, and LUSC are the cancer types where SAMM50 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAMM50 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.326	<.001	9	view →
LIHC	Male	II,III,IV	+1.366	<.001	8	view →
LUSC	Female	All	+0.828	<.001	7	view →
KIRC	Female	All	+0.338	<.001	6	view →
CHOL	Male	All	+1.565	<.001	5	view →
UCEC	All	All	+0.451	.004	4	view →
BRCA	Female	II,III,IV	−0.298	<.001	4	view →
KIRP	All	All	−0.273	.014	2	view →
LUAD	Female	All	+0.209	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SAMM50–THCA

Open the THCA breakdown →