SAMD9L

Across TCGA patient cohorts, SAMD9L mutation is significantly associated with the RNA expression of many other genes, with 6,385 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD9L-associated genes across cancer lineages are NSD2, ALMS1-IT1, and PRC1. Each is linked with SAMD9L in more than 4 cancer types. Because this analysis shows association rather than direction, both SAMD9L-to-partner and partner-to-SAMD9L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NSD2 grouped by SAMD9L-low versus SAMD9L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD9L→partner) and Y-score (partner→SAMD9L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NSD2 →	+0.513	+1.349	<.001	<.001	3	5
HNSC	ALMS1-IT1 →	+0.646	+3.239	<.001	.009	3	5
LUAD	PRC1 →	+0.926	+3.631	<.001	.001	3	5
UCEC	CHAF1A →	+0.773	+2.942	<.001	<.001	3	5
UCEC	FEN1 →	+0.632	+1.748	<.001	<.001	3	5
COAD	MCM5 →	+0.556	+3.857	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,385 associations by consensus.

NSD2 by SAMD9L expression — UCEC

Explore this box plot interactively →