SAMD9L

Across TCGA pan-cancer cohorts, SAMD9L RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SAMD9L data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SAMD9L RNA is associated with better overall survival. In most high-consensus cancer types, elevated SAMD9L expression acts as an unfavorable survival marker, although some lineages such as SKCM and BRCA show a favorable association.

SKCM, UVM, and LGG are the cancer types where SAMD9L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.425	0.236	<.001	126	view →
UVM	DFS	Quartile	III,IV	0.170	0.840	<.001	53	view →
LGG	OS	Median	All	0.707	0.911	<.001	52	view →
BRCA	DFS	Tertile	All	0.923	0.867	.003	47	view →
PAAD	OS	Quartile	All	0.298	0.601	.001	38	view →
CESC	DFS	Tertile	II,III,IV	0.870	0.639	.005	28	view →
KIRP	DFS	Median	III,IV	0.555	0.820	.002	28	view →
CHOL	DFS	Quartile	II,III,IV	0.798	0.213	.003	22	view →
LIHC	OS	Quartile	III,IV	0.715	0.258	.005	22	view →
SARC	OS	Quartile	All	0.828	0.594	<.001	20	view →
UCEC	DFS	Median	All	0.545	0.743	.007	18	view →
KICH	OS	Quartile	II,III,IV	0.597	1.000	.009	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SAMD9L–SKCM (OS)

Open the SKCM breakdown →