SAMD9L

Across TCGA pan-cancer cohorts, SAMD9L RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SAMD9L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SAMD9L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SAMD9L is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where SAMD9L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAMD9L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.967	<.001	9	view →
KIRC	Male	All	+0.888	<.001	9	view →
LUSC	Male	II,III,IV	−1.558	<.001	8	view →
KICH	Male	II,III,IV	−1.543	<.001	7	view →
UCEC	All	II,III,IV	−1.247	<.001	6	view →
STAD	All	All	+0.734	.010	5	view →
ESCA	All	All	+2.031	.004	4	view →
COAD	Female	All	−1.107	<.001	4	view →
BRCA	All	All	+0.323	.013	4	view →
CHOL	All	All	+1.326	.012	2	view →
KIRP	All	IV	+1.310	.001	2	view →
LUAD	All	All	−0.475	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SAMD9L–HNSC

Open the HNSC breakdown →