SAMD9L

Across TCGA patient cohorts, SAMD9L mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD9L-associated genes across cancer lineages are GAPDH, 4E-BP1, and ASNS. Each is linked with SAMD9L in more than 3 cancer types. Because this analysis shows association rather than direction, both SAMD9L-to-partner and partner-to-SAMD9L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by SAMD9L-low versus SAMD9L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD9L→partner) and Y-score (partner→SAMD9L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.623	+3.012	.003	.018	3	4
COAD	4E-BP1 →	+0.251	+1.882	.006	.031	3	4
COAD	ASNS →	+0.678	+1.882	<.001	.031	3	3
COAD	Caspase-7-cleavedD198 →	+1.526	+1.891	<.001	.027	3	3
UCEC	C-Raf →	+0.125	+1.584	<.001	.002	3	3
UCEC	Cyclin-E2 →	+0.119	+0.874	.005	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

GAPDH by SAMD9L expression — COAD

Explore this box plot interactively →