SAMD4B

Across TCGA patient cohorts, SAMD4B mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD4B-associated genes across cancer lineages are Lck, PCNA, and ATM. Each is linked with SAMD4B in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD4B-to-partner and partner-to-SAMD4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by SAMD4B-low versus SAMD4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD4B→partner) and Y-score (partner→SAMD4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.181	+1.765	.016	.014	3	2
UCEC	PCNA →	+0.194	+2.169	.016	.003	3	2
UCEC	ATM →	-0.649	-2.662	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.235	-2.000	.012	.030	3	1
UCEC	eIF4E →	+0.189	+2.321	.016	.005	3	1
UCEC	GATA6 →	-0.166	-2.570	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Lck by SAMD4B expression — UCEC

Explore this box plot interactively →