SAMD4B

Across TCGA pan-cancer cohorts, SAMD4B RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated SAMD4B data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SAMD4B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAMD4B expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

ACC, SCLC, and BLCA are the cancer types where SAMD4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.369	0.780	<.001	84	view →
SCLC	OS	Median	II,III,IV	0.815	0.561	.001	71	view →
BLCA	DFS	Tertile	All	0.140	0.503	<.001	71	view →
UCS	DFS	Median	III,IV	0.656	0.184	<.001	64	view →
MESO	OS	Tertile	III,IV	0.405	0.673	.002	57	view →
LGG	DFS	Median	All	0.633	0.845	<.001	53	view →
LIHC	DFS	Median	All	0.459	0.621	<.001	44	view →
LUAD	DFS	Tertile	All	0.714	0.857	.003	38	view →
UCEC	DFS	Tertile	All	0.785	0.876	.004	34	view →
SKCM	DFS	Quartile	All	0.679	0.896	<.001	30	view →
CESC	DFS	Median	III,IV	0.573	0.880	.002	20	view →
COAD	DFS	Tertile	All	0.621	0.751	.011	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

SAMD4B–ACC (DFS)

Open the ACC breakdown →