SAMD4B

Across TCGA pan-cancer cohorts, SAMD4B RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SAMD4B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SAMD4B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SAMD4B is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where SAMD4B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAMD4B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.023	<.001	12	view →
COAD	Male	II,III,IV	+0.672	<.001	11	view →
KIRC	Female	All	+0.561	<.001	11	view →
LIHC	Female	II,III,IV	+1.511	<.001	9	view →
LUAD	All	III,IV	+0.798	<.001	9	view →
LUSC	Female	All	+1.164	<.001	8	view →
KIRP	All	III,IV	+0.608	.003	8	view →
THCA	All	II,III,IV	−0.317	.002	7	view →
STAD	All	II,III,IV	+0.822	.005	6	view →
BRCA	All	III,IV	+0.513	<.001	6	view →
BLCA	Female	All	+0.457	.005	6	view →
CHOL	Male	All	+2.440	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SAMD4B–HNSC

Open the HNSC breakdown →