SAMD4B

Across TCGA cell cohorts, SAMD4B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,767 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SAMD4B-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription initiation, Negative regulation of transcription initiation by RNA polymerase II, and Transcription pausing by RNA polymerase II. Each is linked with SAMD4B in more than 13 cancer types. Because this analysis shows association rather than direction, both SAMD4B-to-partner and partner-to-SAMD4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription initiation grouped by SAMD4B-low versus SAMD4B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD4B→partner) and Y-score (partner→SAMD4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of DNA-templated transcription initiation →	+0.128	+0.606	<.001	<.001	3	14
BONE	Negative regulation of transcription initiation by RNA polymerase II →	+0.128	+0.606	<.001	<.001	3	14
BONE	Transcription pausing by RNA polymerase II →	+0.168	+0.734	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.086	+0.660	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of protein sumoylation →	+0.099	+0.608	.001	.001	3	14
BONE	Epigenetic regulation of gene expression →	+0.078	+0.563	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,767 associations by consensus.

Negative regulation of DNA-templated transcription initiation by SAMD4B expression — BONE

Explore this box plot interactively →