SAMD4B

Across TCGA cell cohorts, SAMD4B mutation is significantly associated with the RNA expression of many other genes, with 494 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SAMD4B-associated genes across cancer lineages are MTPAP, HIPK3, and CEP97. Each is linked with SAMD4B in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD4B-to-partner and partner-to-SAMD4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTPAP grouped by SAMD4B-low versus SAMD4B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD4B→partner) and Y-score (partner→SAMD4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MTPAP →	+0.699	+3.212	<.001	.006	3	2
LARGE_INTESTINE	HIPK3 →	+0.558	+3.212	.005	.006	3	2
BLOOD_Leukemia	CEP97 →	+0.865	+3.199	<.001	.007	3	2
LARGE_INTESTINE	ZFP90 →	+0.682	+3.212	.005	.006	3	2
LARGE_INTESTINE	FANCG →	+0.541	+3.299	.007	.004	3	2
BLOOD_Lymphoma	OR56A4 →	+0.071	+3.927	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 494 associations by consensus.

MTPAP by SAMD4B expression — LARGE_INTESTINE

Explore this box plot interactively →