SAMD4A

Across TCGA patient cohorts, SAMD4A mutation is significantly associated with the RNA expression of many other genes, with 2,354 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD4A-associated genes across cancer lineages are MAPK6P4, SNORD126, and RPL13P. Each is linked with SAMD4A in more than 2 cancer types. Because this analysis shows association rather than direction, both SAMD4A-to-partner and partner-to-SAMD4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK6P4 grouped by SAMD4A-low versus SAMD4A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD4A→partner) and Y-score (partner→SAMD4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MAPK6P4 →	+0.068	+2.897	.001	<.001	3	3
READ	SNORD126 →	+1.055	+4.202	<.001	.008	3	3
CESC	RPL13P →	+0.026	+4.020	<.001	.009	3	2
UCEC	CCDC163 →	+0.369	+2.518	.005	.001	3	2
UCEC	H2AC4 →	+0.446	+2.625	.002	<.001	3	2
SKCM	CADM2-AS2 →	+0.028	+5.163	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,354 associations by consensus.

MAPK6P4 by SAMD4A expression — COAD

Explore this box plot interactively →