SAMD4A

Across TCGA pan-cancer cohorts, SAMD4A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SAMD4A data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SAMD4A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAMD4A expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UVM, MESO, and KIRC are the cancer types where SAMD4A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.299	0.803	<.001	112	view →
MESO	OS	Median	All	0.256	0.510	<.001	84	view →
KIRC	DFS	Quartile	All	0.923	0.820	.001	41	view →
UCEC	OS	Quartile	All	0.872	0.955	.006	40	view →
ACC	DFS	Quartile	All	0.328	0.843	.002	37	view →
LGG	DFS	Quartile	All	0.747	0.868	.002	29	view →
UCS	DFS	Tertile	IV	0.942	0.239	.024	24	view →
SKCM	DFS	Quartile	All	0.828	0.674	.001	20	view →
KIRP	OS	Median	III,IV	0.158	0.733	.008	16	view →
LUAD	OS	Tertile	III,IV	0.885	0.619	.007	12	view →
CESC	OS	Median	All	0.745	0.844	.023	10	view →
THCA	DFS	Median	All	0.770	0.903	.012	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SAMD4A–UVM (DFS)

Open the UVM breakdown →