SAMD4A

Across TCGA pan-cancer cohorts, SAMD4A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SAMD4A’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SAMD4A RNA is repressed in tumor relative to normal tissue. In most cancer types SAMD4A is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, THCA, and LUAD are the cancer types where SAMD4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAMD4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−1.948	<.001	11	view →
THCA	Male	All	+1.150	<.001	8	view →
LUAD	All	All	−0.649	<.001	8	view →
LUSC	Female	All	−1.773	<.001	7	view →
UCEC	All	III,IV	−2.304	<.001	6	view →
BRCA	All	III,IV	−1.687	<.001	6	view →
HNSC	Female	III,IV	+1.454	<.001	6	view →
COAD	All	II,III,IV	−0.659	.001	6	view →
KICH	Male	All	+0.669	.025	3	view →
READ	Female	All	−1.810	.011	2	view →
STAD	Female	All	−1.105	.039	2	view →
PRAD	All	All	−0.573	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SAMD4A–BLCA

Open the BLCA breakdown →