SAMD4A

Across TCGA cell cohorts, SAMD4A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,755 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SAMD4A-associated GO terms across cancer lineages are Regulation of cell-substrate junction assembly, Regulation of focal adhesion assembly, and Regulation of protein K48-linked ubiquitination. Each is linked with SAMD4A in more than 16 cancer types. Because this analysis shows association rather than direction, both SAMD4A-to-partner and partner-to-SAMD4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction assembly grouped by SAMD4A-low versus SAMD4A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD4A→partner) and Y-score (partner→SAMD4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction assembly →	+0.165	+1.966	<.001	<.001	3	17
BONE	Regulation of focal adhesion assembly →	+0.165	+1.966	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of protein K48-linked ubiquitination →	+0.140	+1.241	<.001	<.001	3	15
BONE	Cellular response to environmental stimulus →	+0.043	+1.713	<.001	<.001	3	14
BONE	Negative regulation of Rho protein signal transduction →	+0.195	+2.103	<.001	<.001	3	14
BONE	Positive regulation of stress fiber assembly →	+0.201	+2.436	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,755 associations by consensus.

Regulation of cell-substrate junction assembly by SAMD4A expression — BONE

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