SAMD4A

Across TCGA cell cohorts, SAMD4A mutation is significantly associated with the RNA expression of many other genes, with 356 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SAMD4A-associated genes across cancer lineages are MT1H, OR1L4, and MBD3L2. Each is linked with SAMD4A in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD4A-to-partner and partner-to-SAMD4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT1H grouped by SAMD4A-low versus SAMD4A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD4A→partner) and Y-score (partner→SAMD4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MT1H →	+0.868	+3.866	.002	.006	3	2
URINARY_TRACT	OR1L4 →	+0.060	+4.087	<.001	.009	3	1
CNS	MBD3L2 →	+2.479	+4.981	<.001	.008	3	1
CNS	PRAMEF6 →	+0.131	+5.754	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR4M1 →	+0.008	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.013	+4.078	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 356 associations by consensus.

MT1H by SAMD4A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →