SAMD4A

Across TCGA cell cohorts, SAMD4A mutation is significantly associated with the mutation status of many other genes, with 3,589 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SAMD4A-associated genes across cancer lineages are DGKH, OGDH, and LRRC8A. Each is linked with SAMD4A in more than 2 cancer types. Because this analysis shows association rather than direction, both SAMD4A-to-partner and partner-to-SAMD4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DGKH grouped by SAMD4A-low versus SAMD4A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD4A→partner) and Y-score (partner→SAMD4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DGKH →	+5.044	+5.614	.003	.003	1	3
CNS	OGDH →	+4.459	+5.277	.005	.005	1	3
CNS	LRRC8A →	+4.459	+5.277	.005	.005	1	3
CNS	AP2A1 →	+6.044	+6.044	.001	.001	1	3
LUNG_NSCLC_LUAD	RBM10 →	+3.263	+3.851	.005	.005	1	3
LUNG_NSCLC_LUAD	RAD54L →	+5.000	+4.187	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,589 associations by consensus.

DGKH by SAMD4A expression — CNS

Explore this box plot interactively →