SALL4

Across TCGA patient cohorts, SALL4 mutation is significantly associated with the RNA expression of many other genes, with 3,734 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SALL4-associated genes across cancer lineages are PIMREG, TYMSOS, and SNRPD1. Each is linked with SALL4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SALL4-to-partner and partner-to-SALL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIMREG grouped by SALL4-low versus SALL4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SALL4→partner) and Y-score (partner→SALL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PIMREG →	+0.680	+3.824	.006	<.001	2	6
UCEC	TYMSOS →	+0.653	+1.617	<.001	<.001	3	4
LUAD	SNRPD1 →	+0.498	+3.231	.005	.009	3	4
COAD	MAP3K8 →	-0.553	-2.793	.001	.003	3	4
UCEC	GINS2 →	+0.670	+1.627	<.001	<.001	3	4
UCEC	SNRPA1 →	+0.255	+2.058	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,734 associations by consensus.

PIMREG by SALL4 expression — STAD

Explore this box plot interactively →