SALL3

Across TCGA patient cohorts, SALL3 mutation is significantly associated with the RNA expression of many other genes, with 8,009 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SALL3-associated genes across cancer lineages are C18orf25, ZNF121, and ADNP2. Each is linked with SALL3 in more than 6 cancer types. Because this analysis shows association rather than direction, both SALL3-to-partner and partner-to-SALL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf25 grouped by SALL3-low versus SALL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SALL3→partner) and Y-score (partner→SALL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C18orf25 →	+0.495	+2.010	<.001	<.001	3	7
UCEC	ZNF121 →	+0.456	+2.353	<.001	<.001	3	5
UCEC	ADNP2 →	+0.699	+2.021	<.001	<.001	3	5
COAD	SMAD2 →	+0.390	+2.155	.004	.009	2	6
UCEC	EXOSC9 →	+0.499	+2.523	<.001	<.001	3	5
STAD	IER3IP1 →	+0.467	+2.236	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,009 associations by consensus.

C18orf25 by SALL3 expression — UCEC

Explore this box plot interactively →