SALL3

Across TCGA pan-cancer cohorts, SALL3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SALL3 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SALL3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SALL3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and STAD show a favorable association.

KIRC, THCA, and UVM are the cancer types where SALL3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	II,III,IV	0.420	0.621	<.001	109	view →
THCA	DFS	Median	II,III,IV	0.773	0.908	.002	90	view →
UVM	OS	Tertile	All	0.355	0.821	.002	67	view →
ACC	DFS	Tertile	All	0.161	0.583	<.001	60	view →
HNSC	OS	Median	III,IV	0.792	0.669	.004	50	view →
UCEC	DFS	Quartile	All	0.765	0.874	<.001	40	view →
MESO	OS	Quartile	All	0.384	0.621	.008	37	view →
LGG	DFS	Median	All	0.332	0.473	<.001	30	view →
STAD	OS	Tertile	IV	0.742	0.151	.018	24	view →
SCLC	DFS	Tertile	II,III,IV	0.910	0.152	.006	18	view →
GBM	DFS	Quartile	All	0.306	0.179	.020	15	view →
LUAD	OS	Tertile	II,III,IV	0.765	0.553	.022	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SALL3–KIRC (DFS)

Open the KIRC breakdown →