SALL3

Across TCGA pan-cancer cohorts, SALL3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SALL3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SALL3 RNA is repressed in tumor relative to normal tissue. In most cancer types SALL3 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and BRCA are the cancer types where SALL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SALL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	−1.357	<.001	9	view →
KIRC	All	All	−0.997	<.001	8	view →
BRCA	All	II,III,IV	+0.060	<.001	6	view →
LUAD	All	All	+0.259	.003	5	view →
LUSC	All	All	+0.577	<.001	4	view →
BLCA	All	All	−0.446	.003	4	view →
KICH	Male	II,III,IV	−0.985	.011	3	view →
HNSC	Male	II,III,IV	+0.405	.038	2	view →
HNSC	Female	All	−0.071	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 8 lineages.

SALL3–KIRP

Open the KIRP breakdown →