SALL3

Across TCGA patient cohorts, SALL3 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SALL3-associated genes across cancer lineages are ATM, Mre11, and P-Cadherin. Each is linked with SALL3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SALL3-to-partner and partner-to-SALL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SALL3-low versus SALL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SALL3→partner) and Y-score (partner→SALL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.390	-1.473	.004	.006	3	4
STAD	Mre11 →	-0.122	-2.563	.004	.010	3	3
STAD	P-Cadherin →	-0.144	-3.000	.016	.033	3	3
UCEC	JNK2 →	+0.203	+2.834	<.001	.001	3	3
UCEC	Shc_pY317 →	-0.119	-1.440	.010	.022	3	3
UCEC	Bcl-2 →	-0.300	-1.236	.004	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

ATM by SALL3 expression — UCEC

Explore this box plot interactively →