SALL3

Across TCGA cell cohorts, SALL3 mutation is significantly associated with the RNA expression of many other genes, with 1,656 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SALL3-associated genes across cancer lineages are ELP5, GATAD2B, and ABHD18. Each is linked with SALL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SALL3-to-partner and partner-to-SALL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELP5 grouped by SALL3-low versus SALL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SALL3→partner) and Y-score (partner→SALL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELP5 →	+0.707	+1.969	<.001	<.001	3	3
LARGE_INTESTINE	GATAD2B →	+0.426	+1.628	.002	.002	3	3
LARGE_INTESTINE	ABHD18 →	+0.516	+1.969	<.001	<.001	3	3
LARGE_INTESTINE	ELMOD2 →	+0.374	+3.404	.004	<.001	3	3
LUNG_SCLC	SLC36A3 →	+0.011	+2.847	.002	.009	3	2
SOFT_TISSUE	LBHD2 →	+0.152	+3.295	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,656 associations by consensus.

ELP5 by SALL3 expression — LARGE_INTESTINE

Explore this box plot interactively →