SAGE1

Across TCGA patient cohorts, SAGE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,124 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SAGE1-associated GO terms across cancer lineages are Cytoplasmic translation, Spindle assembly, and tRNA metabolic process. Each is linked with SAGE1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SAGE1-to-partner and partner-to-SAGE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic translation grouped by SAGE1-low versus SAGE1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAGE1→partner) and Y-score (partner→SAGE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cytoplasmic translation →	+0.058	+0.471	<.001	<.001	3	13
STAD	Spindle assembly →	+0.049	+0.510	<.001	<.001	3	12
ESCA	tRNA metabolic process →	+0.047	+1.018	.001	<.001	3	12
STAD	Protein folding →	+0.059	+0.461	<.001	<.001	3	12
STAD	Regulation of isotype switching →	+0.059	+0.592	<.001	<.001	3	12
STAD	Positive regulation of isotype switching →	+0.058	+0.600	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,124 associations by consensus.

Cytoplasmic translation by SAGE1 expression — STAD

Explore this box plot interactively →