SAGE1

RNA — tumor vs normal
Tumor vs NormalRNABox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, SAGE1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SAGE1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SAGE1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SAGE1 is over-expressed in tumor.

KIRP, HNSC, and STAD are the cancer types where SAGE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAGE1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
KIRPFemaleII,III,IV+0.054.0295view →
HNSCAllAll+0.318.0263view →
STADAllAll+0.472.0222view →
LUSCAllAll+0.438.0182view →
KIRCMaleAll+0.069.0152view →
KICHAllAll+0.112.0151view →
LUADMaleAll+0.043.0061view →
THCAAllAll+0.021.0181view →
COADAllAll+0.014.0341view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SAGE1–KIRP

Tumor-vs-normal expression box plot for SAGE1 RNA in KIRP.

Open the KIRP breakdown →

Exploration