SAGE1

Across TCGA pan-cancer cohorts, SAGE1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SAGE1 data layer compared with 11 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher SAGE1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SAGE1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

COAD, SKCM, and SCLC are the cancer types where SAGE1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	All	0.792	0.892	.001	124	view →
SKCM	OS	Quartile	All	0.847	0.762	.005	42	view →
SCLC	OS	Median	All	0.827	0.624	.003	33	view →
LAML	DFS	Tertile	All	0.418	0.631	.008	20	view →
LIHC	OS	Tertile	All	0.674	0.814	.015	18	view →
DLBC	OS	Tertile	IV	0.342	0.930	.045	18	view →
MESO	OS	Quartile	All	0.871	0.342	.013	18	view →
UCEC	OS	Median	II,III,IV	0.697	0.826	.012	16	view →
ACC	DFS	Median	III,IV	0.816	0.297	.006	15	view →
LUAD	DFS	Median	IV	0.293	0.640	.007	14	view →
LGG	OS	Quartile	All	0.348	0.524	.002	13	view →
STAD	DFS	Quartile	IV	0.159	0.536	.020	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SAGE1–COAD (OS)

Open the COAD breakdown →