SAGE1

Across TCGA patient cohorts, SAGE1 mutation is significantly associated with the RNA expression of many other genes, with 5,243 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAGE1-associated genes across cancer lineages are POLD3, NUSAP1, and NUF2. Each is linked with SAGE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SAGE1-to-partner and partner-to-SAGE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLD3 grouped by SAGE1-low versus SAGE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAGE1→partner) and Y-score (partner→SAGE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLD3 →	+0.418	+1.509	<.001	<.001	3	5
UCEC	NUSAP1 →	+0.783	+2.618	<.001	<.001	3	4
SKCM	NUF2 →	+0.679	+2.430	<.001	<.001	3	4
UCEC	BUB3 →	+0.402	+2.245	<.001	<.001	3	4
UCEC	SKA1 →	+0.740	+2.629	<.001	<.001	3	4
SKCM	TTC9C →	+0.261	+1.530	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,243 associations by consensus.

POLD3 by SAGE1 expression — UCEC

Explore this box plot interactively →