SAGE1

Across TCGA cell cohorts, SAGE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 577 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SAGE1-associated GO terms across cancer lineages are Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Positive regulation of Wnt signaling pathway, and Regulation of telomere maintenance. Each is linked with SAGE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SAGE1-to-partner and partner-to-SAGE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay grouped by SAGE1-low versus SAGE1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAGE1→partner) and Y-score (partner→SAGE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.089	+2.687	.001	<.001	3	4
LIVER	Positive regulation of Wnt signaling pathway →	-0.069	-2.460	<.001	.008	3	4
CNS	Regulation of telomere maintenance →	+0.031	+0.572	.001	.006	3	3
CNS	Cardiac muscle contraction →	-0.051	-0.813	.002	.007	2	4
CNS	Telomere maintenance →	+0.031	+0.550	.001	.008	3	3
LUNG_NSCLC_LUAD	Protein localization to microtubule cytoskeleton →	+0.055	+1.476	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 577 associations by consensus.

Positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay by SAGE1 expression — LIVER

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