SAGE1

Across TCGA cell cohorts, SAGE1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SAGE1-associated genes across cancer lineages are LRRC72, ABCC12, and CXorf51A. Each is linked with SAGE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAGE1-to-partner and partner-to-SAGE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC72 grouped by SAGE1-low versus SAGE1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAGE1→partner) and Y-score (partner→SAGE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LRRC72 →	+0.070	+4.285	<.001	.007	3	2
LUNG_SCLC	ABCC12 →	+0.114	+4.000	<.001	.001	3	1
LUNG_SCLC	CXorf51A →	+0.082	+3.353	<.001	.001	3	1
LUNG_SCLC	ELOA3BP →	+0.153	+3.381	<.001	.007	3	1
LUNG_SCLC	ITIH1 →	+0.111	+3.032	<.001	.004	3	1
SKIN	PRRT1B →	+0.023	+2.791	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

LRRC72 by SAGE1 expression — STOMACH

Explore this box plot interactively →