SAFB

Across TCGA patient cohorts, SAFB mutation is significantly associated with the RNA expression of many other genes, with 2,287 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAFB-associated genes across cancer lineages are MIR6832, LINC01753, and RNU6-470P. Each is linked with SAFB in more than 2 cancer types. Because this analysis shows association rather than direction, both SAFB-to-partner and partner-to-SAFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6832 grouped by SAFB-low versus SAFB-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAFB→partner) and Y-score (partner→SAFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR6832 →	+0.905	+3.879	<.001	.004	3	3
LUSC	LINC01753 →	+0.161	+4.625	<.001	.008	3	3
COAD	RNU6-470P →	+0.119	+4.239	<.001	.005	3	3
CESC	SNORD111 →	+0.448	+3.872	.008	.004	3	2
READ	FRG2 →	+0.028	+5.653	<.001	.003	3	2
READ	LINC00408 →	+0.145	+5.925	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,287 associations by consensus.

MIR6832 by SAFB expression — HNSC

Explore this box plot interactively →