SAFB

Across TCGA pan-cancer cohorts, SAFB RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SAFB data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SAFB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAFB expression acts as an unfavorable survival marker, although some lineages such as UCEC and PAAD show a favorable association.

ACC, KIRP, and LIHC are the cancer types where SAFB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.268	0.637	<.001	78	view →
KIRP	DFS	Median	II,III,IV	0.277	0.691	.001	60	view →
LIHC	DFS	Tertile	All	0.437	0.630	<.001	55	view →
UCEC	OS	Tertile	III,IV	0.900	0.771	.003	42	view →
PAAD	DFS	Tertile	All	0.421	0.180	.001	39	view →
THYM	DFS	Median	All	0.897	0.421	.001	28	view →
KIRC	DFS	Quartile	III,IV	0.751	0.417	.011	26	view →
MESO	DFS	Tertile	IV	0.306	0.837	.001	24	view →
GBM	DFS	Tertile	All	0.454	0.189	.003	20	view →
COAD	DFS	Median	All	0.428	0.604	.005	19	view →
PRAD	DFS	Quartile	All	0.676	0.906	.003	16	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SAFB–ACC (DFS)

Open the ACC breakdown →