SAA1

Across TCGA patient cohorts, SAA1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAA1-associated genes across cancer lineages are JNK2, Ku80, and Myosin-IIa_pS1943. Each is linked with SAA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAA1-to-partner and partner-to-SAA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SAA1-low versus SAA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAA1→partner) and Y-score (partner→SAA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.475	+3.169	<.001	.020	3	1
UCEC	Ku80 →	+0.273	+3.183	.035	.010	3	1
UCEC	Myosin-IIa_pS1943 →	+0.262	+3.183	.020	.010	3	1
UCEC	Myosin-IIa →	+0.289	+2.818	.004	.035	3	1
UCEC	p21 →	+0.231	+3.169	.029	.020	3	1
UCEC	Tuberin_pT1462 →	+0.321	+3.169	.011	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

JNK2 by SAA1 expression — UCEC

Explore this box plot interactively →