SAA1

Across TCGA pan-cancer cohorts, SAA1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SAA1 data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SAA1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAA1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and BRCA show a favorable association.

KIRC, LGG, and UVM are the cancer types where SAA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.513	0.742	<.001	135	view →
LGG	DFS	Median	All	0.664	0.808	<.001	51	view →
UVM	DFS	Median	All	0.442	0.689	.007	40	view →
OV	OS	Median	IV	0.473	0.754	.002	32	view →
LUSC	OS	Quartile	III,IV	0.624	0.222	.002	30	view →
BRCA	OS	Median	All	0.581	0.558	.003	29	view →
LIHC	DFS	Quartile	II,III,IV	0.338	0.150	.003	27	view →
UCS	DFS	Median	III,IV	0.141	0.452	.021	24	view →
KIRP	DFS	Median	All	0.867	0.951	.004	23	view →
CHOL	OS	Median	II,III,IV	0.268	0.974	.003	20	view →
STAD	DFS	Quartile	II,III,IV	0.519	0.763	.003	17	view →
COAD	OS	Quartile	IV	0.428	0.870	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SAA1–KIRC (DFS)

Open the KIRC breakdown →