SAA1

Across TCGA pan-cancer cohorts, SAA1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SAA1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SAA1 RNA is repressed in tumor relative to normal tissue. In most cancer types SAA1 is over-expressed in tumor, although a few such as BRCA and LIHC show the opposite, repressed pattern.

BRCA, KIRC, and LIHC are the cancer types where SAA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−5.340	<.001	8	view →
KIRC	Male	All	+2.230	<.001	8	view →
LIHC	Female	II,III,IV	−6.119	<.001	6	view →
LUAD	Female	II,III,IV	+2.478	<.001	6	view →
KICH	All	All	−1.609	<.001	6	view →
COAD	All	II,III,IV	+1.192	.012	3	view →
LUSC	Male	All	+1.164	.007	3	view →
CHOL	Female	All	−4.033	.014	2	view →
ESCA	All	All	+2.983	.004	2	view →
KIRP	Male	All	+1.826	.016	2	view →
THCA	All	All	+0.547	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SAA1–BRCA

Open the BRCA breakdown →