S1PR2

Across TCGA cell cohorts, S1PR2 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible S1PR2-associated genes across cancer lineages are ELOA3DP, NAA11, and LRRC3C. Each is linked with S1PR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both S1PR2-to-partner and partner-to-S1PR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by S1PR2-low versus S1PR2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR2→partner) and Y-score (partner→S1PR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ELOA3DP →	+0.208	+4.007	<.001	.002	3	2
LARGE_INTESTINE	NAA11 →	+0.350	+3.443	.002	.009	3	1
LARGE_INTESTINE	LRRC3C →	+0.253	+3.099	.001	.004	3	1
LARGE_INTESTINE	FAM205A →	+0.018	+3.614	<.001	.006	3	1
LARGE_INTESTINE	TBC1D3 →	+0.078	+3.103	<.001	.004	3	1
BLOOD_Leukemia	SLC32A1 →	+0.736	+3.771	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ELOA3DP by S1PR2 expression — BLOOD_Leukemia

Explore this box plot interactively →