S1PR2

Across TCGA pan-cancer cohorts, S1PR2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated S1PR2 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher S1PR2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated S1PR2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

KIRP, KIRC, and MESO are the cancer types where S1PR2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	II,III,IV	0.330	0.746	<.001	108	view →
KIRC	OS	Median	All	0.565	0.692	.001	95	view →
MESO	OS	Tertile	II,III,IV	0.172	0.512	<.001	83	view →
ACC	DFS	Tertile	All	0.217	0.612	<.001	82	view →
HNSC	DFS	Median	III,IV	0.671	0.507	<.001	79	view →
ESCA	OS	Quartile	II,III,IV	0.745	0.354	.001	56	view →
LUAD	OS	Tertile	III,IV	0.719	0.238	<.001	56	view →
UVM	DFS	Tertile	All	0.407	0.802	.001	44	view →
CESC	OS	Tertile	IV	0.869	0.295	.015	40	view →
UCEC	DFS	Quartile	IV	0.813	0.259	.004	36	view →
LIHC	OS	Tertile	III,IV	0.380	0.697	.010	18	view →
DLBC	DFS	Median	All	0.963	0.684	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

S1PR2–KIRP (DFS)

Open the KIRP breakdown →