S100Z

Across TCGA patient cohorts, S100Z mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S100Z-associated genes across cancer lineages are mTOR_pS2448, Notch1, and PKC-b-II_pS660. Each is linked with S100Z in more than 1 cancer types. Because this analysis shows association rather than direction, both S100Z-to-partner and partner-to-S100Z results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by S100Z-low versus S100Z-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100Z→partner) and Y-score (partner→S100Z) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.190	-3.169	.020	.020	3	1
UCEC	Notch1 →	+0.264	+3.169	<.001	.020	3	1
UCEC	PKC-b-II_pS660 →	-0.392	-3.169	.009	.020	3	1
UCEC	Rab25 →	-0.433	-3.169	.017	.020	3	1
UCEC	STAT3_pY705 →	-0.674	-3.169	<.001	.018	3	1
UCEC	p62 Lck ligand →	+0.414	+3.169	.020	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

mTOR_pS2448 by S100Z expression — UCEC

Explore this box plot interactively →