S100Z

Across TCGA cell cohorts, S100Z mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible S100Z-associated genes across cancer lineages are PRG3, P2RY12, and ZNF804B. Each is linked with S100Z in more than 1 cancer types. Because this analysis shows association rather than direction, both S100Z-to-partner and partner-to-S100Z results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRG3 grouped by S100Z-low versus S100Z-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100Z→partner) and Y-score (partner→S100Z) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRG3 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	P2RY12 →	+0.114	+4.273	.009	.006	3	1
LARGE_INTESTINE	ZNF804B →	+0.011	+4.415	.009	.007	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1
LARGE_INTESTINE	IQCF6 →	+0.311	+4.467	<.001	.004	3	1
LARGE_INTESTINE	C1orf232 →	+0.024	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PRG3 by S100Z expression — LARGE_INTESTINE

Explore this box plot interactively →