S100A7

Across TCGA patient cohorts, S100A7 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S100A7-associated genes across cancer lineages are Tuberin, MEK1, and p27_pT157. Each is linked with S100A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both S100A7-to-partner and partner-to-S100A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by S100A7-low versus S100A7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A7→partner) and Y-score (partner→S100A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.403	+2.817	.006	.036	3	1
UCEC	MEK1 →	+0.443	+3.169	.027	.020	1	1
UCEC	p27_pT157 →	-0.074	-3.169	.020	.020	1	1
UCEC	ARID1A →	-0.277	-2.992	.008	.036	1	1
UCEC	Di-Ras3 →	-0.182	-3.169	.025	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Tuberin by S100A7 expression — UCEC

Explore this box plot interactively →