S100A7

Across TCGA cell cohorts, S100A7 RNA expression is significantly associated with the go_rna of many other GO terms, with 872 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible S100A7-associated GO terms across cancer lineages are Positive regulation of iron ion transport, Positive regulation of iron ion transmembrane transport, and NMDA selective glutamate receptor signaling pathway. Each is linked with S100A7 in more than 5 cancer types. Because this analysis shows association rather than direction, both S100A7-to-partner and partner-to-S100A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of iron ion transport grouped by S100A7-low versus S100A7-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A7→partner) and Y-score (partner→S100A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of iron ion transport →	+1.285	+1.925	<.001	.009	3	6
BREAST	Positive regulation of iron ion transmembrane transport →	+1.285	+1.925	<.001	.009	3	6
BREAST	NMDA selective glutamate receptor signaling pathway →	+0.137	+2.058	.001	<.001	3	5
BREAST	Response to fungicide →	+0.084	+1.957	.001	.008	3	5
UPPER_AERODIGESTIVE_TRACT	Micturition →	-1.149	-3.880	.006	.001	3	5
URINARY_TRACT	Regulation of synoviocyte proliferation →	-0.200	-2.417	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 872 associations by consensus.

Positive regulation of iron ion transport by S100A7 expression — BREAST

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