S100A12

Across TCGA cell cohorts, S100A12 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,361 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible S100A12-associated GO terms across cancer lineages are Peptidyl-cysteine modification, Leukocyte migration involved in inflammatory response, and Chronic inflammatory response. Each is linked with S100A12 in more than 5 cancer types. Because this analysis shows association rather than direction, both S100A12-to-partner and partner-to-S100A12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-cysteine modification grouped by S100A12-low versus S100A12-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (S100A12→partner) and Y-score (partner→S100A12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Peptidyl-cysteine modification →	+0.119	+1.298	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	Leukocyte migration involved in inflammatory response →	+0.176	+1.745	<.001	<.001	3	6
BLOOD_Leukemia	Chronic inflammatory response →	+0.656	+0.732	<.001	<.001	3	6
BREAST	Post-translational protein targeting to endoplasmic reticulum membrane →	+0.057	+0.380	.003	<.001	3	5
BREAST	Urea transmembrane transport →	+1.012	+0.333	.008	.006	2	6
BREAST	NMDA selective glutamate receptor signaling pathway →	+0.146	+0.333	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,361 associations by consensus.

Peptidyl-cysteine modification by S100A12 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →